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Stay away from concomitant utilization of tucatinib with CYP3A substrates, where negligible concentration alterations may produce major or existence-threatening toxicities. If unavoidable, cut down CYP3A substrate dose according to item labeling.Belzutifan is a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may well enhance incidence o